Yearbook of Pediatric Endocrinology 2012 , livre ebook

S. Karger AG

Découvre YouScribe en t'inscrivant gratuitement

Je m'inscris

Obtenez un accès à la bibliothèque pour le consulter en ligne
En savoir plus

315 pages

English

Vous pourrez modifier la taille du texte de cet ouvrage

Obtenez un accès à la bibliothèque pour le consulter en ligne
En savoir plus

A propos
Informations
Extrait

Description

The body of knowledge in most medical specialties is rapidly expanding, making it virtually impossible to follow all advances in clinical and basic sciences that are relevant to a given field. This is particularly true in pediatric endocrinology, at the cross-road of pediatrics, endocrinology, development and genetics. Providing abstracts of articles that report the year’s breakthrough developments in the basic sciences and evidence-based new knowledge in clinical research and clinical practice that are relevant to the field, the Yearbook of Pediatric Endocrinology 2012 keeps busy clinicians and scientists, pediatric endocrinologists, and also pediatricians and endocrinologists informed on new advances. Twelve Associate Editors and their co-authors selected from several thousand papers those that brought the most meaningful new information, summarized them and provided comments to put them into perspective. The papers are classified into those that identify new genes involved in diseases, new hormones, concepts revised or re-centered, important observations for clinical practice, large-scale clinical trials, new mechanisms, new paradigms, important review articles, new fears and new hopes. Because the Yearbook is endorsed by the European Society for Paediatric Endocrinology (ESPE), its publication is linked to the annual meeting of the ESPE. The Yearbook of Pediatric Endocrinology 2012 covers the medical and scientific literature from June 2011 through May 2012.

Informations

Publié par	S. Karger AG
Date de parution	01 octobre 2012
Nombre de lectures	0
EAN13	9783318022315
Langue	English
Poids de l'ouvrage	1 Mo

Informations légales : prix de location à la page 0,0205€. Cette information est donnée uniquement à titre indicatif conformément à la législation en vigueur.

Extrait

Yearbook of Pediatric Endocrinology 2012
Yearbook of Pediatric Endocrinology 2012
Endorsed by the European Society for Paediatric Endocrinology
Editors
Ken Ong
Ze’ev Hochberg
Associate Editors
Gary Butler
Evangelia Charmandari
Francesco Chiarelli
Stefano Cianfarani
Mehul Dattani
Nicolas De Roux
Helmuth-Günther Dörr
Outi Mäkitie
Orit Pinhas-Hamiel
Michel Polak
Olle Söder
Martin Wabitsch
Sponsored by a grant from Pfizer Endocrine Care
Disclaimer. The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publisher and the editor(s). The appearance of advertisements in the book is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
Drug Dosage. The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any change in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
© Copyright 2012 by S. Karger AG, P.O. Box, CH-4009 Basel (Switzerland)
www.karger.com
Printed in Switzerland on acid-free and non-aging paper (ISO 9706) by Reinhardt Druck, Basel
ISBN 978-3-318-02230-8
ISSN 1662-3391
Editors
Ken Ong
Medical Research Council Epidemiology Unit
Institute of Metabolic Science, Addenbrooke’s Hospital, Box 285
Cambridge CB2 0QQ, UK
Tel. +44 1223 769207, Fax +44 1223 330316, E-Mail ken.ong@mrc-epid.cam.ac.uk
Ze’ev Hochberg
Meyer Children’s Hospital, Rambam Medical Center, Faculty of Medicine
Technion-Israel Institute of Technology, POB 9602
IL-31096 Haifa, Israel
Fax +972 4 854 21 57, E-Mail z_hochberg@rambam.health.gov.il
Associate Editors
Gary E. Butler
Department of Paediatrics and Adolescent Endocrinology
University College London Hospital, 250 Euston Road
London NW1 2PQ, UK
Tel. +44 203 447 9455
E-Mail gary.butler@ucl.ac.uk
Evangelia Charmandari
Division of Endocrinology, Metabolism and Diabetes
First Department of Pediatrics
University of Athens Medical School
‘Aghia Sophia’ Children’s Hospital
GR-11527 Athens, Greece
Tel. +30 210 659 7196, Fax +30 210 659 7545, E-Mail evangelia.charmandari@googlemail.com
Francesco Chiarelli
Department of Pediatrics, University of Chieti, Via dei Vestini, 5
IT-66013 Chieti, Italy
Tel +39 0871 358015, Fax +39 0871 574831, E-Mail chiarelli@unich.it
Stefano Cianfarani
Department of Systems Medicine
Tor Vergata University and
Bambino Gesù Children’s Hospital, Rome
P.zza Sant’Onofrio, 4
IT-00165 Rome, Italy
Tel. +39 06 6859 3074, Fax +39 06 6859 2508, E-Mail stefano.cianfarani@uniroma2.it
Mehul T. Dattani
Developmental Endocrine Research Group
Clinical and Molecular Genetics Unit, Institute for Child Health
University College London
30 Guilford Street
London, WC1N 1EH, UK
Tel. +44 207 905 2657, Fax +44 207 404 6191, E-Mail m.dattani@ucl.ac.uk
Nicolas De Roux
INSERM U 690, Laboratoire d’Hormonologie, AP-HP
Hôpital Robert Debré, 48 Boulevard Sérurier
FR-75019 Paris, France
Tel. +33 1 40 03 19 85, Fax +33 1 40 40 91 95, E-Mail nicolas.deroux@inserm.fr
Helmuth-Günther Dörr
Pediatric Endocrinology, Department of Pediatrics
University of Erlangen, Loschgestr. 15
DE-91054 Erlangen, Germany
Tel. +49 9131 85 33732, Fax +49 9131 85 36131, E-Mail Helmuth-Guenther.Doerr@uk-erlangen.de
Outi Mäkitie
Pediatric Endocrinology and Metabolic Bone Diseases
Children’s Hospital
Helsinki University Central Hospital and University of Helsinki
FI-00029 Helsinki, Finland
Tel. +358 9 4711, Fax +358 9 471 75888, E-Mail outi.makitie@helsinki.fi
Orit Pinhas-Hamiel
Pediatric Endocrine and Diabetes Unit
Safra Children’s Hospital
Sheba Medical Center Ramat-Gan
IL–52621 Ramat-Gan, Israel
Tel. +972 3 5305015, Fax +972 3 5305055, E-Mail orit.hamiel@sheba.health.gov.il
Michel Polak
Paediatric Endocrinology, Gynecology and Diabetology INSERM U845
Université Paris Descartes
Hôpital Necker-Enfants Malades
149, rue de Sèvres
FR- 75015 Paris, France
Tel. +33 1 44 49 48 03/02, Fax +33 1 44 38 16 48, E-Mail michel.polak@nck.aphp.fr
Olle Söder
Pediatric Endocrinology Unit, Q2:08
Department of Woman and Child Health
Karolinska Institutet and University Hospital, Solna
SE–171 76 Stockholm, Sweden
Tel. +46 8 517 75124, Fax +46 8 517 75128, E-Mail olle.soder@ki.se
Martin Wabitsch
Division of Pediatric Endocrinology and Diabetes Endocrine Research Laboratory
Department of Pediatrics and Adolescent Medicine
University of Ulm, Eythstrasse 24
DE-89075 Ulm, Germany
Tel. +49 731 5005 7400, Fax +49 731 5005 7407, E-Mail martin.wabitsch@uniklinik-ulm.de
Table of Contents
Preface
Ze’ev Hochberg and Ken Ong
Neuroendocrinology
Lukas Huijbregts, Lucie Chevrier and Nicolas de Roux
Pituitary
Evelien F. Gevers, Carles Gaston-Massuet and Mehul T. Dattani
Thyroid
Gabor Szinnai, Mireille Castanet, Aurore Carré and Michel Polak
Growth and Growth Factors
Stefano Cianfarani
Bone, Growth Plate and Mineral Metabolism
Outi Mäkitie and Ola Nilsson
Reproductive Endocrinology
Lena Sahlin and Olle Söder
Adrenals
Erica L.T. van den Akker and Evangelia Charmandari
Oncology and Chronic Disease
Thomas M.K. Völkl, Tilman Rohrer and Helmuth-Günther Dörr
Type 1 Diabetes: Clinical and Experimental
M. Loredana Marcovecchio and Francesco Chiarelli
Obesity and Weight Regulation
Martin Wabitsch, Daniel Tews, Christian Denzer, Anja Moss, Belinda Lennerz, Julia von Schnurbein and Pamela Fischer-Posovszky
Type 2 Diabetes, Metabolic Syndrome and Lipids
Orit Pinhas-Hamiel
Evidence-Based Medicine in Pediatric Endocrinology and Diabetes
Gary Butler, Carrie Williams, Lee Hudson and Stephen O’Riordan
Editor’s Choice
Ken Ong and Ze’ev Hochberg
Science and Medicine
Ze’ev Hochberg and Ken Ong
Author Index
Subject Index
Preface
The 2012 Yearbook of Pediatric Endocrinology brings you summaries of the year’s published breakthrough developments in the basic sciences and new evidence-based knowledge that are relevant to clinical practice in this field. This is the ninth edition and the Associate Editors will present their chapters at the European Society for Paediatric Endocrinology (ESPE) annual meeting in Leipzig 2012. This year, we introduce a new chapter on endocrine ‘Oncology and Chronic Disease’, while articles on population genetics are now distributed throughout the chapters.
This was another stimulating year (June 2011 to June 2012, when we submit the manuscripts to the publisher). New treatments tested include: insulin degludec and sensor-augmented pumps in type 1 diabetes; dual-release hydrocortisone in adrenal insufficiency; gefinitib and pasireotide in Cushing’s disease; enzyme-replacement therapy in life-threatening hypophosphatasia; antenatal thyroid screening, and cholesterol-lowering foods in hyperlipidemia. In the basic sciences, (a) a new hormone ‘irisin’ was discovered, the first to be secreted by skeletal muscle, with beneficial effects on adipose tissue; (b) significant advance was made in laboratory culture of stem cells towards the goal of growing ‘a pituitary in a dish’; (c) two separate whole-exome sequencing studies identified activating mutations in the PI3K/AKT/mTOR pathway as causes of overgrowth and insulin overactivity; (d) the Aboriginal Australian genomic sequence was found to represent one of the oldest continuous populations outside Africa, with no evidence of European admixture, and (e) the brain was identified as an evolutionary target; genes expressed in the neocortex arose soon after its morphological origin.
On 31 October, 2011, the world’s population reached 7 billion, with 3 billion being children and the subjects of our care, as members of the world’s pediatricians. Concerns over the expanding population seem to be abating, but the sheer number poses challenges for health and the environment. One billion people are hungry and the planet’s resources are stretched thin. We all know what needs to be done: empower women in all aspects of life; reduce poverty as the root cause of hunger; distribute wealth more fairly; increase food production – through genetically engineered crops; develop renewable energy sources, and avoid fur