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Description

Dry eye is one of the most common disorders encountered in ophthalmological practice. Its symptoms cause considerable discomfort and substantially reduce the patient’s quality of life. As it is a complex and multifactorial condition, research investigating dry eye is a matter of great interest all over the world.In this book, the wide range of current basic and clinical research in dry eye and correlated ocular surface diseases is presented by scientists from Germany, Austria and the USA. These renowned authors provide clear and extensive descriptions of their projects, enabling scientists and clinical ophthalmologists to quickly bring themselves up to date with cutting edge research in this field.This overview of research into the pathogenesis and clinical treatment of dry eye is a must for all ophthalmologists dealing with this syndrome and looking to increase their knowledge base.

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Publié par	S. Karger AG
Date de parution	11 mai 2010
Nombre de lectures	0
EAN13	9783805594196
Langue	English
Poids de l'ouvrage	1 Mo

Informations légales : prix de location à la page 0,0170€. Cette information est donnée uniquement à titre indicatif conformément à la législation en vigueur.

Extrait

Research Projects in Dry Eye Syndrome
Developments in Ophthalmology
Vol. 45
Series Editors
F. Bandello     Milan
W. Behrens-Baumann     Magdeburg

Research Projects in Dry Eye Syndrome
Volume Editor
Horst Brewitt     Hannover
54 figures, 1 in color, and 8 tables, 2010
_________________________
Horst Brewitt Ubbenstrasse 11 DE-30159 Hannover
This book was generously supported by

Library of Congress Cataloging-in-Publication Data
Research projects in dry eye syndrome / volume editor, Horst Brewitt.
p. ; cm. -- (Developments in ophthalmology, ISSN 0250-3751 ; v. 45)
Includes bibliographical references and index.
ISBN 978-3-8055-9418-9 (hard cover: alk. paper)
1. Dry eye syndromes. I. Brewitt, H. (Horst) II. Series: Developments in ophthalmology, v. 45. 0250-3751 ;
[DNLM: 1. Dry Eye Syndromes. W1 DE998NG v.45 2010 / WW 208 R432 2010]
RE216.D78R47 2010
617.7'1--dc22
2010007067
Bibliographic Indices. This publication is listed in bibliographic services, including Current Contents® and Index Medicus.
Disclaimer. The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publisher and the editor(s). The appearance of advertisements in the book is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
Drug Dosage. The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any change in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
© Copyright 2010 by S. Karger AG, P.O. Box, CH–4009 Basel (Switzerland)
www.karger.com
Printed in Switzerland on acid-free and non-aging paper (ISO 9706) by Reinhardt Druck, Basel
ISSN 0250-3751
ISBN 978-3-8055-9418-9
e-ISBN 978-3-8055-9419-6

Contents
List of Contributors
Preface
Brewitt, H. (Hannover)
Trefoil Factor Family Peptide 3 at the Ocular Surface. A Promising Therapeutic Candidate for Patients with Dry Eye Syndrome?
Schulze, U.; Sel, S.; Paulsen, F.P. (Halle/Saale)
Cationic Amino Acid Transporters and β-Defensins in Dry Eye Syndrome
Jäger, K.; Garreis, F.; Dunse, M.; Paulsen, F.P. (Halle/Saale)
Antimicrobial Peptides as a Major Part of the Innate Immune Defense at the Ocular Surface
Garreis, F.; Gottschalt, M.; Paulsen, F.P. (Halle/Saale)
Regulation of the Inflammatory Component in Chronic Dry Eye Disease by the Eye-Associated Lymphoid Tissue (EALT)
Knop, N. (Hannover); Knop, E. (Berlin)
Intravital Multidimensional Real-Time Imaging of the Conjunctival Immune System
Gehlsen, U.; Hüttmann, G.; Steven, P. (Lübeck)
Generation of Two- and Three-Dimensional Lacrimal Gland Constructs
Schrader, S. (London/Lübeck); Liu, L. (Birmingham); Kasper, K.; Geerling, G. (Würzburg)
Midterm Results of Cultivated Autologous and Allogeneic Limbal Epithelial Transplantation in Limbal Stem Cell Deficiency
Pauklin, M.; Fuchsluger, T.A.; Westekemper, H.; Steuhl, K.-P.; Meller, D. (Essen)
Laser Scanning Confocal Microscopy for Conjunctival Epithelium Imaging
Jürgens, C.; Rath, R.; Giebel, J.; Tost, F.H.W. (Greifswald)
Pollen Enzymes Degrade Human Tear Fluid and Conjunctival Cells: An Approach to Understanding Seasonal Non-Allergic Conjunctivitis
Rabensteiner, D.F.; Spreitzhofer, E.; Trummer, G.; Wachswender, C.; Kirchengast, S.; Horwath-Winter, J.; Schmut, O. (Graz)
Towards a New in vitro Model of Dry Eye: The ex vivo Eye Irritation Test
Spöler, F.; Frentz, M.; Schrage, N.F. (Aachen)
The Lid Margin Is an Underestimated Structure for Preservation of Ocular Surface Health and Development of Dry Eye Disease
Knop, E. (Berlin); Korb, D.R.; Blackie, C.A. (Boston, Mass.); Knop, N. (Hannover)
Diagnostic Markers of Sjögren's Syndrome
Witte, T. (Hannover)
Hyperosmolarity of the Tear Film in Dry Eye Syndrome
Messmer, E.M.; Bulgen, M.; Kampik, A. (Munich)
Novel Ocular Lubricant Containing an Intelligent Delivery System: Details of Its Mechanism of Action
Springs, C. (Indianapolis, Ind.)
Author Index
Subject Index

List of Contributors
Caroline A. Blackie, Dr.
Korb Associates
400 Commonwealth Ave.
Unit 2
Boston, MA 02215 (USA)
E-Mail cblackie@tearscience.com
Horst Brewitt, Prof. Dr.
Ubbenstrasse 11
DE–30159 Hannover (Germany)
E-Mail HorstBrewitt@T-Online.de
Meral Bulgen
Department of Ophthalmology
Ludwig Maximilian University
Mathildenstrasse 8
DE–80336 Munich (Germany)
E-Mail meral.bulgen@yahoo.de
Matthias Dunse
Department of Anatomy and Cell Biology
Martin Luther University Halle-Wittenberg
Grosse Steinstrasse 52
DE–06097 Halle/Saale (Germany)
E-Mail info@matthiasdunse.de
Markus Frentz
Department of Ophthalmology
RWTH Aachen University
Pauwelsstraße 30
DE–52074 Aachen (Germany)
E-Mail frentz@acto.de
Thomas A. Fuchsluger, Dr.
Department of Ophthalmology
University of Duisburg-Essen
Hufelandstrasse 55
DE–45122 Essen (Germany)
E-Mail thomas.fuchsluger@uk-essen.de
Fabian Garreis
Department of Anatomy and Cell Biology
Martin Luther University Halle-Wittenberg
Grosse Steinstrasse 52
DE–06097 Halle/Saale (Germany)
E-Mail fabian.garreis@medizin.uni-halle.de
Gerd Geerling, Prof. Dr.
Klinik für Augenheilkunde
Julius Maximilians Universität Würzburg
Josef-Schneider-Str. 11
DE–97080 Würzburg
E-Mail G.Geerling@augenklinik.uni-wuerzburg.de
U. Gehlsen, Dr.
Department of Ophthalmology
University Medical Center Schleswig-Holstein
Campus Lübeck, Ratzeburger Allee 160
DE–23538 Lübeck (Germany)
E-Mail gehlsen@anat.uni-luebeck.de
Jürgen Giebel, Prof. Dr.
Institute of Anatomy and Cell Biology
Ernst-Moritz-Arndt University
Friedrich-Loeffler-Str. 23c
DE–17487 Greifswald (Germany)
E-Mail giebel@uni-greifswald.de
Maria Gottschalt, Dr.
Department of Anatomy and Cell Biology
Martin Luther University Halle-Wittenberg
Grosse Steinstrasse 52
DE–06097 Halle/Saale (Germany)
E-Mail maria.gottschalt@web.de
Jutta Horwath-Winter, Dr.
Department of Ophthalmology
Medical University of Graz
Auenbruggerplatz 4
AT–8036 Graz (Austria)
E-Mail jutta.horwath@medunigraz.at
Gereon Hüttmann, Dr.
Biomedical Optics
University of Lübeck
Peter-Monnik-Weg 4
DE–23562 Lübeck (Germany)
E-Mail huettmann@bmo.uni-luebeck.de
Kristin Jäger, Dr.
Department of Anatomy and Cell Biology
Martin Luther University Halle-Wittenberg
Grosse Steinstrasse 52
DE–06097 Halle/Saale (Germany)
E-Mail kristin.jaeger@medizin.uni-halle.de
Clemens Jürgens, Dr.
Klinik für Augenheilkunde
Ernst-Moritz-Arndt-Universität Greifswald
Ferdinand-Sauerbruch-Strasse
DE–17475 Greifswald (Germany)
E-Mail juergens@uni-greifswald.de
Anselm Kampik, Prof. Dr.
Augenklinik der LMU
Klinikum der Universität München
Campus Innenstadt
Mathildenstrasse 8
DE–80336 Munich (Germany)
E-Mail akampik@med.uni-muenchen.de
Karsten Kasper
Department of Ophthalmology
Julius Maximilian University Würzburg
Josef-Schneider-Straße 11
DE–97080 Würzburg (Germany)
E-Mail k-augen@augenklinik.uniwuerzburg.de
Sieglinde Kirchengast
Department of Ophthalmology
Medical University of Graz
Auenbruggerplatz 4
AT–8036 Graz (Austria)
E-Mail sieglinde.kirchengast@ medunigraz.at
Erich Knop, Dr.
Research Laboratory of the Department of
Ophthalmology CVK
Charité – Universitätsmedizin Berlin
Ziegelstrasse 5–9
DE–10117 Berlin (Germany)
E-Mail erich.knop@charite.de
Nadja Knop, Dr.
Department of Cell Biology in Anatomy
Hannover Medical School
Carl-Neuberg-Strasse 1
DE–30625 Hannover (Germany)
E-Mail knopnadja@aol.com
Donald R. Korb, Prof. Dr.
Korb Associates
400 Commonwealth Ave.
Unit 2
Boston, MA 02215 (USA)
E-Mail drkorb@aol.com
L. Liu, Dr.
Academi