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413 pages

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The pulmonary circulation is by nature difficult to evaluate for the clinician and a challenge to investigate by radiographic and hemodynamic methods. In recent years, the field has been revolutionized by major improvements in diagnostic approaches and therapies. Tools for the classification, diagnosis, and management of pulmonary embolism and pulmonary hypertension have been developed and optimized, providing clinicians with detailed and updated guidelines. This volume provides the latest information on the fast-growing and challenging field of acute and chronic pulmonary vascular disorders from some of the field’s major leaders in research, education, and care. The topics discussed are relevant to chest physicians, thoracic surgeons, nurses, students, and teachers, and a well-balanced mix of contributions ensures that doctors, clinicians, and institutions from all around the world will find the information presented to be both informative and useful to their situations.

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Publié par	S. Karger AG
Date de parution	10 avril 2012
Nombre de lectures	0
EAN13	9783805599153
Langue	English
Poids de l'ouvrage	1 Mo

Informations légales : prix de location à la page 0,0622€. Cette information est donnée uniquement à titre indicatif conformément à la législation en vigueur.

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Pulmonary Vascular Disorders
Progress in Respiratory Research
Vol.41
Series Editor
Chris T. Bolliger    Cape Town

Pulmonary Vascular Disorders
Volume Editors
Marc Humbert     Clamart
Rogerio Souza     Sao Paulo
Gérald Simonneau     Clamart
82 figures, 21 in color, 45 tables, 2012
Marc Humbert, MD, PhD Service de Pneumologie et Réanimation Respiratoire Centre National de Référence de l'Hypertension Artérielle Pulmonaire Sévère Inserm U999 Hôpital Antoine Béclère Asssitance Publique Hôpitaux de Paris Université Paris-Sud 11 157, rue de la Porte de Trivaux F-92140 Clamart France
Rogerio Souza, MD, PhD Pulmonary Circulation Unit Pulmonary Department Heart Institute University of Sao Paulo Medical School Av. Dr. Eneas de Carvalho Aguiar, 44 Sao Paulo 05403-000 Brazil
Gérald Simonneau, MD Service de Pneumologie et Réanimation Respiratoire Centre National de Référence de l'Hypertension Artérielle Pulmonaire Sévère Inserm U999 Hôpital Antoine Béclère Asssitance Publique Hôpitaux de Paris Université Paris-Sud 11 157, rue de la Porte de Trivaux F-92140 Clamart France
Library of Congress Cataloging-in-Publication Data
Pulmonary vascular disorders / volume editors, Marc Humbert, Rogerio Souza, Gérald Simonneau.
p.; cm.-- (Progress in respiratory research, ISSN 1422-2140; v. 41)
Includes bibliographical references and indexes.
ISBN 978-3-8055-9914-6 (hard cover: alk. paper) - ISBN 978-3-8055-9915-3 (e-ISBN)
I. Humbert, Marc, 1963- II. Souza, Rogerio. III. Simonneau, Gérald. IV. Series: Progress in respiratory research, v. 41. 1422-2140
[DNLM: 1. Hypertension, Pulmonary. 2. Vascular Diseases. W1 PR681DM v.41 2012 / WG 340]
616.2'4--dc23
2012002107
Bibliographic Indices. This publication is listed in bibliographic services, including Current Contents®.
Disclaimer. The statements, opinions and data contained in this publication are solely those f the individual authors and contributors and not of the publisher and the editor(s). The appearance of advertisements in the book is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
Drug Dosage. The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any change in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
© Copyright 2012 by S. Karger AG, P.O. Box, CH-4009 Basel (Switzerland)
www.karger.com
Printed in Germany on acid-free and non-aging paper (ISO 9706) by Bosch-Druck GmbH, Ergolding
ISSN 1422–2140
e-ISSN 1662–3932
ISBN 978–3–8055–9914–6
e-ISBN 978–3–8055–9915–3
Contents
Foreword
Preface
Chapter 1 Updated Clinical Classification of Pulmonary Hypertension
Montani, D.; Simonneau, G. (Clamart)
Chapter 2 Pathology of Pulmonary Arterial Hypertension
Dorfmüller, P. (Le Plessis Robinson)
Chapter 3 Invasive Rest and Exercise Hemodynamics in the Modern Management of Pulmonary Vascular Disease: An Expanding Role in the Future
Whyte, K.F. (Auckland); Hervé, P. (Le Plessis-Robinson); Hoette, S.; Chemla, D. (Clamart)
Chapter 4 Exercise Testing in Pulmonary Arterial Hypertension
Provencher, S.; Mainguy, V. (Québec, Qué.)
Chapter 5 Noninvasive Exploration of the Pulmonary Circulation and the Right Heart
Vonk Noordegraaf, A. (Amsterdam); Peacock, A. (Glasgow); Naeije, R. (Brussels)
Chapter 6 Biomarkers in Pulmonary Arterial Hypertension
Souza, R.; Hoette, S.; Dias, B.; Jardim, C. (Sao Paulo)
Chapter 7 Genetics of Pulmonary Arterial Hypertension and the Concept of Heritable Pulmonary Arterial Hypertension
Girerd, B.; Montani, D.; Yaici, A. (Clamart); Eyries, M.; Coulet, F.; Soubrier, F. (Paris); Humbert, M. (Clamart)
Chapter 8 Drug- and Toxin-Induced Pulmonary Arterial Hypertension
Price, L.; Bouillon, K.; Wort, S.J. (London); Humbert, M. (Clamart)
Chapter 9 Idiopathic Pulmonary Arterial Hypertension and Its Prognosis in the Modern Management Era in Developed and Developing Countries
Jiang, X. (Shanghai); Humbert, M. (Clamart); Jing, Z.-C. (Shanghai)
Chapter 10 Pulmonary Arterial Hypertension Complicating Connective Tissue Disorders
Le Pavec, J. (Clamart); Hassoun, P.M. (Baltimore, Md.)
Chapter 11 Pulmonary Arterial Hypertension and HIV and Other Viral Infections
Degano, B.; Valmary, S. (Besançon); Sitbon, O.; Humbert, M. (Clamart)
Chapter 12 Portopulmonary Hypertension and Hepatopulmonary Syndrome
Savale, L.; Hervé, P.; Sitbon, O. (Clamart)
Chapter 13 Pulmonary Hypertension in Congenital Heart Diseases
Tissot, C.; Beghetti, M. (Geneva)
Chapter 14 Pulmonary Hypertension in Sickle Cell Disease
Parent, F.; Savale, L. (Clamart); Maitre, B. (Créteil); Simonneau, G. (Clamart)
Chapter 15 Schistosomiasis and Pulmonary Hypertension
Fernandes, C.J.C.; Jardim, C.; Hovnanian, A.; Hoette, S.; Morinaga, L.K.; Souza, R. (Sao Paulo)
Chapter 16 Pulmonary Veno-Occlusive Disease
Montani, D.; Huertas, A.; Dorfmüller, P.; Humbert, M. (Clamart)
Chapter 17 Pulmonary Hypertension and Left Heart Disease
Adir, Y. (Haifa); Galiè, N. (Bologna)
Chapter 18 Pulmonary Hypertension in Chronic Obstructive Pulmonary Disease
Weitzenblum, E. (Strasbourg); Chaouat, A. (Nancy); Canuet, M.; Ducoloné, A.; Kessler, R. (Strasbourg)
Chapter 19 Pulmonary Hypertension Complicating Interstitial and Granulomatous Lung Diseases
Nunes, H.; Uzunhan, Y.; Gille, T. (Bobigny); Dauriat, G. (Paris); Brauner, M.; Kambouchner, M.; Valeyre, D. (Bobigny)
Chapter 20 High-Altitude Pulmonary Hypertension
Di, R.-M.; Jing, Z.-C. (Shanghai)
Chapter 21 Acute Pulmonary Venous Thromboembolic Disease
Sanchez, O.; Meyer, G. (Paris)
Chapter 22 Anticoagulation for Venous Thromboembolism in the Modern Management Era
Le Gal, G.; Leroyer, C.; Mottier, D. (Brest)
Chapter 23 Chronic Thromboembolic Pulmonary Hypertension
Lang, I.M. (Vienna); Jais, X. (Clamart)
Chapter 24 Medical Treatment of Pulmonary Arterial Hypertension
O'Callaghan, D.S. (Clamart); Gaine, S.P. (Dublin)
Chapter 25 Lung Transplantation and Role for Novel Extracorporeal Support in Pulmonary Hypertension
Hoeper, M.M. (Hannover)
Chapter 26 Atrial Septostomy
Vachiéry, J.-L. (Brussels)
Chapter 27 Pulmonary Vascular Disorders in Hereditary Hemorrhagic Telangiectasia
Cottin, V.; Khouatra, C; Dupuis-Girod, S.; Cordier, J.-F. (Lyon)
Chapter 28 Future Perspectives in Pulmonary Arterial Hypertension
Rubin, L.J. (La Jolla, Calif.)
Author Index
Subject Index

Foreword
The aim of Progress in Respiratory Research , the so-called blue series, has always been to cover a broad range of topics in respiratory medicine. When looking for a topic for the next volume to follow the most recent one on Antituberculosis Chemotherapy (vol. 40), I realized that we never had an entire book dedicated to pulmonary vascular disorders during my tenure as series editor. I actually had to go back all the way to 1990, i.e. 22 years ago, to find the last such volume entitled: Pulmonary Blood Vessels in Lung Disease. While paging through it, I was stunned to realize how much progress has been made during the last two decades. On the therapeutic side for primary pulmonary hypertension, the only options that were discussed back then were the use of warfarin and a first hint at calcium channel blockers, which probably would have to have been administered in high doses. It was thus clear to me that we urgently needed a state-of-the-art update in that field.
To ask Marc Humbert to become a volume editor was an easy choice, and to my delight he not only accepted the task but also brought along two other eminent specialists, Rogerio Souza and Gérald Simonneau, as volume co-editors. As usual for Progress in Respiratory Research , the 'who's who' were invited from all over the world to contribute chapters to the current book and cover the entire range of pulmonary vascular disorders. Careful attention was paid to have the latest scientific findings reported.
The result is an outstanding stand-alone volume which - as the volume editors mention in the following Preface - should appeal to health care providers interested in the field, ranging from nurses to top specialists in the field.
I hope that you as the