Frequent RASSF1A gene promoter hypermethylation in breast cancer [Elektronische Ressource] / presented by Yan Zhang

Universitätsklinikum Ulm Klinik für Frauenheilkunde und Geburtshilfe (Ärztlicher Direktor: Prof. Dr. Kreienberg) Frequent RASSF1A Gene Promoter Hypermethylation in Breast Cancer Dissertation for the attainment of the Doctoral Degree of Medicine (Dr. med.) at the Faculty of Medicine, University of Ulm, Ulm, Germany Presented by Yan Zhang born in Shenyang, Liaoning Province, P. R. China 2008 Amtierender Dekan: Prof.Dr.Klaus-Michael Debatin 1. Berichterstatter: Prof.R.Kreienberg 2. Berichterstatter: Prof.L.Kinzl Tag der Promotion: 29.05.2008 Content Content Abbreviations……………………………………………………………… III 1 Introduction........................................................................................... 1 1.1 Breast cancer........................................................................................ 1 1.1.1 Overview of breast cancer ................................................................... 1 1.1.2 Clinical classification ........................................................................... 1 1.2 Genetic and expression aberrant of genes in breast cancer............ 3 1.3 Epigenetic alteration in tumorigenesis............................................... 4 1.3.1 DNA methylation................................................................................... 4 1.3.2 Histone modifications .......................................................................... 5 1.3.