A recruitment maneuver increases oxygenation after intubation of hypoxemic intensive care unit patients: a randomized controlled study

biomed - Constantin Jean-Michel , Futier Emmanuel , Cherprenet Anne-Laure , Chanques Gérald , Renaud Guerin , Cayot-Constantin Sophie , Jabaudon Mathieu , Perbet Sebastien , Chartier Christian , Jung Boris , Guelon Dominique , Jaber Samir , Jean-Etienne Bazin

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11 pages

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Tracheal intubation and anaesthesia promotes lung collapse and hypoxemia. In acute lung injury patients, recruitment maneuvers (RMs) increase lung volume and oxygenation, and decrease atelectasis. The aim of this study was to evaluate the efficacy and safety of RMs performed immediately after intubation. Methods This randomized controlled study was conducted in two 16-bed medical-surgical intensive care units within the same university hospital. Consecutive patients requiring intubation for acute hypoxemic respiratory failure were included. Patients were randomized to undergo a RM immediately (within 2 minutes) after intubation, consisting of a continuous positive airway pressure (CPAP) of 40 cmH 2 O over 30 seconds (RM group), or not (control group). Blood gases were sampled and blood samples taken for culture before, within 2 minutes, 5 minutes, and 30 minutes after intubation. Haemodynamic and respiratory parameters were continuously recorded throughout the study. Positive end expiratory pressure (PEEP) was set at 5 cmH 2 O throughout. Results The control (n = 20) and RM (n = 20) groups were similar in terms of age, disease severity, diagnosis at time of admission, and PaO 2 obtained under 10-15 L/min oxygen flow immediately before (81 ± 15 vs 83 ± 35 mmHg, P = 0.9), and within 2 minutes after, intubation under 100% FiO 2 (81 ± 15 vs 83 ± 35 mmHg, P = 0.9). Five minutes after intubation, PaO 2 obtained under 100% FiO 2 was significantly higher in the RM group compared with the control group (93 ± 36 vs 236 ± 117 mmHg, P = 0.008). The difference remained significant at 30 minutes with 110 ± 39 and 180 ± 79 mmHg, respectively, for the control and RM groups. No significant difference in haemodynamic conditions was observed between groups at any time. Following tracheal intubation, 15 patients had positive blood cultures, showing microorganisms shared with tracheal aspirates, with no significant difference in the incidence of culture positivity between groups. Conclusions Recruitment maneuver following intubation in hypoxemic patients improved short-term oxygenation, and was not associated with increased adverse effects. Trial registration NCT01014299

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Publié par	biomed
Publié le	01 janvier 2010
Nombre de lectures	11
Langue	English

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Constantinet al.Critical Care2010,14:R76 http://ccforum.com/content/14/2/R76

R E S E A R C H Open Access Research A recruitment maneuver increases oxygenation after intubation of hypoxemic intensive care unit patients: a randomized controlled study

1 1 1 2 1 Jean-Michel Constantin* , Emmanuel Futier , Anne-Laure Cherprenet , Gérald Chanques , Renaud Guerin , 1 1 1 1 2 Sophie Cayot-Constantin , Mathieu Jabaudon , Sebastien Perbet , Christian Chartier , Boris Jung , 3 2 1 Dominique Guelon , Samir Jaber and Jean-Etienne Bazin

Introductiontion to extubation, remains a high-risk procedure [2,3]. In the ICU, acute respiratory failure is a common prob- Endotracheal intubation is a well-known cause of marked lem that usually requires endotracheal intubation [1]. changes in respiratory mechanics and gas exchange [4,5]. Airway management in critically ill patients, from intuba- When intubation is used to treat respiratory failure, underlying patient pathology can increase such modifica-* Correspondence: jmconstantin@chu-clermontferrand.fr 1tions and the reduction in lung volume results in deep General ICU, Department of Anesthesiology and Critical-Care, Estaing Hospital, University Hospital of Clermont-Ferrand, 1 Place Lucie Aubrac, 63000hypoxemia after intubation. Moreover, mechanical venti-Clermont-Ferrand, France Full list of author information is available at the end of the article © 2010 Constantin et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Com-mons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduc-BioMedCentral tion in any medium, provided the original work is properly cited.