Structural bioinformatics: current status and future directions

• leçon - matière potentielle : from eight years of distributed computing

Structural bioinformatics: current status and future directions Swanand Gore∗, Sameer Velankar and Gerard J. Kleywegt Protein Data Bank in Europe (PDBe) EMBL-EBI Wellcome Trust Genome Campus, Hinxton, Cambridge 1 Introduction Structural biology is a key discipline in basic and applied biological research. It reveals atomic and mechanistic details of biological macromolecules in normal and diseased states and en- ables researchers to modulate the molecular machinery in a rational manner, through the design of important molecules of practical relevance such as drugs, inhibitors, enzymes, antibodies, pesticides etc. Structural bioinformatics - an umbrella term encompassing many techniques in biocomputing and informatics of macromolecular structures - is an essential

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