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Collège - Lycée

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BACKGROUND Platelet activating factor PAF seems to be implicated in systemic lupus erythematosus SLE patients with associated renal diseases Aims In this study we ensured the role of PAF in SLE patients without renal complications Methods Blood PAF and acetylhydrolase activity plasma soluble phospholipase A2 and the presence of antibodies against PAF were investigated in SLE patients without active nephritis and in healthy controls Results Blood PAF levels were not different p between SLE patients pg ml and healthy subjects pg ml Plasma acetylhy drolase activity the PAF degrading enzyme was significantly p elevated in SLE patients nmol min ml as compared with controls nmol min ml Plasma soluble phospholi pase A2 the key enzyme for PAF formation was not different p between SLE patients U ml and controls U ml Antibodies against PAF were detected only in SLE patients Flow cytometry analysis did not highlight PAF receptors on circulating leukocytes of SLE patients Conclusion This clinical study highlights no evi dence for a putative important role of PAF in SLE patients without active nephritis icon
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Documents scolaires

Collège - Lycée

BACKGROUND Platelet activating factor PAF seems to be implicated in systemic lupus erythematosus SLE patients with associated renal diseases Aims In this study we ensured the role of PAF in SLE patients without renal complications Methods Blood PAF and acetylhydrolase activity plasma soluble phospholipase A2 and the presence of antibodies against PAF were investigated in SLE patients without active nephritis and in healthy controls Results Blood PAF levels were not different p between SLE patients pg ml and healthy subjects pg ml Plasma acetylhy drolase activity the PAF degrading enzyme was significantly p elevated in SLE patients nmol min ml as compared with controls nmol min ml Plasma soluble phospholi pase A2 the key enzyme for PAF formation was not different p between SLE patients U ml and controls U ml Antibodies against PAF were detected only in SLE patients Flow cytometry analysis did not highlight PAF receptors on circulating leukocytes of SLE patients Conclusion This clinical study highlights no evi dence for a putative important role of PAF in SLE patients without active nephritis

Yves Denizot1
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