VITO proteins are essential new cofactors of the muscle regulatory network [Elektronische Ressource] / von Michał Mielcarek

VITO proteins are essential new cofactors of the muscle regulatory network Doctoral Thesis zur Erlangung des akademischen Grades Dr. rer. nat. vorgelegt der Mathematisch-Naturwissenschaftlich-Technischen Fakultät der Martin-Luther-Universität Halle-Wittenberg von Micha ł Mielcarek Geb. am: 21 September 1976 in Pozna ń, Poland Reviewers: 1. Prof. Dr. T. Braun 2. Prof. Dr. R. Renkawitz-Pohl 3. Prof. Dr. E. Wahle 02.03.2007 Halle (Saale) urn:nbn:de:gbv:3-000011638[http://nbn-resolving.de/urn/resolver.pl?urn=nbn%3Ade%3Agbv%3A3-000011638] CONTENT 1. Introduction 1 1.1. Regulation of transcription in vertebrates 1 1.2. Transcription regulation in skeletal and cardiac muscles 3 1.3. Transcription Enhancer Factors (TEF) family 4 1.3.1. Evolution and structure of TEFs family 4 1.3.2. Expression and regulation of Transcription Enhancer Factor members 6 1.3.2.1. TEF-1 6 1.3.2.2. TEF-3 8 1.3.2.3. TEF-4 9 1.3.2.4. TEF-5 10 1.3.3. Biological function of TEF gene family 11 1.3.3.1. Role of TEFs in skeletal muscles 13 1.3.3.2. Regulation of transcription in cardiac muscles by TEFs 14 1.3.4. Co-activators of TEFs 17 1.3.4.1. YAP65 and TAZ as co-activators of TEFs 17 1.3.4.2.