Unconventional T lymphocytes [Elektronische Ressource] : recombinant MHC molecules pave the way = Unkonventionelle T-Lymphozyten / vorgelegt von Steffen Walter

Unconventional T lymphocytes - recombinant MHC molecules pave the way Unkonventionelle T Lymphozyten - rekombinante MHC-Moleküle eröffnen neue Wege D I S S E R T A T I O N der Fakultät für Chemie und Pharmazie der Eberhard-Karls-Universität Tübingen zur Erlangung des Grades eines Doktors der Naturwissenschaften 2005 vorgelegt von Steffen Walter 2 Unconventional T cells - recombinant MHC molecules pave the way Unconventional T cells - recombinant MHC molecules pave the way 3 Tag der mündlichen Prüfung: 1. April 2005 Dekan: Prof. Dr. S. Laufer 1. Berichterstatter: Prof. Stevanovi ć 2. Berichterstatter: Dr. H.-G. Rammensee 4 Unconventional T cells - recombinant MHC molecules pave the way Contents General Introduction Chapter 1 5 Cutting Edge: Predetermined avidity of human CD8 T Chapter 2 50 cells expanded on calibrated MHC/anti-CD28 coated microspheres +HLA class I restricted CD4 T cells in congenital viral Chapter 3 70 infection High frequencies of functionally impaired cytokeratin 18-Chapter 4 80 +specific CD8 T cells in healthy HLA-A2+ donors Summary / Zusammenfassung 108 Abbreviations 110 Academic Teachers 111 Danksagung 112 Publications 114 Scholarships and awards 116 Curriculum Vitae / Lebenslauf 117 Unconventional T cells - recombinant MHC molecules pave the way 5 1 General Introduction 1.