Two-pore domain K_1hn+ channel TASK-1 in human pulmonary artery smooth muscle cells and its regulation by the vasoconstrictor endothelin-1 [Elektronische Ressource] / vorgelegt von Tang, Bi

+Two-pore domain K channel TASK-1 in human pulmonary artery smooth muscle cells and its regulation by the vasoconstrictor endothelin-1 Inauguraldissertation Zur Erlangung des Grades eines Doktors der Medizin des Fachbereichs Medizin der Justus-Liebig Universität Giessen vorgelegt von Tang, Bi MD aus Ling Bi, Anhui province, China Gießen, 2010 Aus dem Zentrum für Innere Medizin, Medizinische Klinik und Poliklinik II, Pneumologie und Intensivmedizin Direktor: Prof. Dr. Werner Seeger Gutachter: Prof. DDr. T. Braun Gutachter: Prof. Dr. A. Olschewski Tag der Disputation: 06. 07. 2010 My wife, Pingping Sun, for her constant interest and her continuous helpfulness My family for the continuous support and encouragement during my doctoral dissertation Table of contents 1. Introduction and question……………………………………………………. ……1 2. Potassium channels in human pulmonary artery smooth muscle cells (PASMCs)………………………………………………………………………………6 3. Background two-pore domain potassium channels (K )……… ….………7 2P4. TASK-1 channels in PASMCs……………………………………………………..10 5. Role of endothelin-1 in pulmonary hypertension (PH) .……………………..12 6. Materials and Methods…………………………………………………………….14 6.