Tropical - software for quantitative analysis of FRAP experiments [Elektronische Ressource] : identifying the dynamics of linker histone H1? / presented by Markus Ulrich

Dissertation submitted to the Combined Faculties for the Natural Sciences and for Mathematics of the Ruperto-Carola University of Heidelberg, Germany for the degree of Doctor of Natural Sciences presented by Diplom-Biologe Markus Ulrich born in: Ludwigshafen / Rhein, Germany Oral-examination: April 2008 Tropical – Software for quantitative analysis of FRAP experiments -Identifying the dynamics of linker histone H1°- Referees: Prof. Dr. Roland Eils Prof. Dr. Harald Herrmann-Lerdon Acknowledgements First I would like to thank Prof. Dr. Roland Eils for welcoming me in a wonderful, in-ternational and interdisciplinary group at the renowned German Cancer Research Center, DKFZ. Prof. Roland Eils steadily supported my work and ideas, particularly in times when it was most needed. I’d like to thank him for showing continuous trust into the success of my project, for helpful discussions and the many valuable contacts to scientists in this field of research. Prof. Dr. Harald Herrmann-Lerdon deserves many thanks for support of this thesis, creative ideas and critical discussions concerning the experimental part of my work. I also thank him for the opportunity to use his cell culture lab. Special thanks go to Dr.