TrkB and gene expression [Elektronische Ressource] / presented by Anna Maria Calella

Dissertationsubmitted to theCombined Faculties for the Natural Sciences and for Mathematicsof the Ruperto-Carola University of Heidelberg, Germanyfor the degree ofDoctor of Natural Sciencespresented byDiplom-Pharmaceutical Chemist: Anna Maria CalellaBorn in: Putignano (Italy) Oral examination: 27.11.2003TrkB and gene expressionReferees: Prof. Dr. Claus Nerlov Prof. Dr. Klaus UnsickerTable of contentsAcknowledgements ivPublications during the PhD period vAbbreviations viList of figures and tables viiiAbstract ix1 Introduction 11.1 The nervous system arises from the ectoderm 21.2 Cortical development 41.3 Basic Helix-Loop-Helix factors in cortical development 71.3.1 Maintenance of neural progenitors 81.3.2 Formation of neurons 111.4 C/EBP transcription factors 131.4.1 C/EBPs: homology regions1.4.2 C/EBPs in neuronal cells 151.5 Neurotrophins signaling 171.5.1 Signal transduction through the Trk receptors 191.5.2 Neurotrophins and cortical progenitors 211.6 Proto-oncogene fos: complex but versatile regulation 231.7 mGif/TIEG1 transcription factor 251.8 The thesis project 28 2 Results 302.1 Differential regulation of immediate early genes induced byBDNF through the shc-site or the plcg-site of the TrkB receptor 312.