Transfer of lipophilic drugs between liposomal membranes by using the ion-exchange micro-column technique and the fluorescence dequenching effect [Elektronische Ressource] / von Xiaoyi Zhu

Transfer of lipophilic drugs between liposomal membranes by using the ion-exchange micro-column technique and the fluorescence dequenching effect Dissertation zur Erlangung des akademischen Grades doctor rerum naturalium (Dr. rer. nat.) vorgelegt dem Rat der Biologisch-Pharmazeutischen Fakultät der Friedrich-Schiller- Universität Jena von Xiaoyi Zhu geboren am 28.04.1982 in Shandong, China ii Gutachter: Prof. Dr. Alfred Fahr (Friedrich-Schiller-Universität Jena) Prof. Dr. Gerhard Scriba (Friedrich-Schiller-Universität Jena) rrit Scherphof (University of Groningen; NL) Tag der öffentlichen Verteidigung: 18.12.2008 iii iv You cannot teach a man anything; you can only help him find it within himself Galileo Galilei (1564-1642) v vi To my parents, Zhu Qi and Wang Ping, y mi Hanghang vii viii Acknowledgements The accomplishment of this thesis would not have been possible without many people’s support. First and foremost, I would like to express my sincere gratitude to my mentor Prof. Dr. Alfred Fahr, for offering me the opportunity to do research in this exciting field and for supporting and guiding me throughout the course of my Ph.D. project.