Transcriptional regulation of the Xenopus MyoD gene [Elektronische Ressource] / vorgelegt von Lei Xiao

Transcriptional Regulation of the Xenopus MyoD GeneDissertation der Fakultät für Biologieder Ludwig-Maximilians-Universität MünchenVorgelegt vonLei XiaoAus Hubei, China2003thDissertation eingereicht: 11 , June, 2003Berichterstatter: Prof. Dr. Dirk EickSonderberichterstatter: Prof. Dr. Ralph A. W. RuppthTag der mündlichen Prüfung: 25 , July, 2003AcknowledgementsI am indebted to my parents and my wife for their longstanding support, withoutwhich any of my achievements would not have been possible.I would like to express gratitude to my supervisor, Prof. Dr. Ralph Rupp, forguiding me throughout my PhD study. I am immensely thankful to Prof. Dr. Dirk Eickfor supporting and helpful comments on this thesis.I wish to thank my colleagues from Prof. Dr. Rupp’s lab for their help and advice.Especially Dr. Ryan Cabot and Nishant Singhal for their help of correcting English.Table of contentsTable of contents1 SUMMARY 12 INTRODUCTION 22.1 Early development and mesoderm patterning of Xenopus 22.1.1 Frog embryology 22.1.2 Mesoderm induction 42.2 Muscle development 62.3 MRF expression in vertebrate embryos 72.3.1 MRF expression in muscle progenitors of the mouse embryo 72.3.2 MRF expression in muscle progenitors of the frog embryo 82.4 Functional and genetic relationships of the MRFs 92.4.1 Myogenic functions of MRFs 92.4.2 Genetic analysis of Myf5 and MyoD functions in progenitorspecification 102.4.