Transcriptional regulation in the early phase of liver regeneration ; Transkripcinis ankstyvojo kepenų regeneracijos tarpsnio reguliavimas

VYTAUTASMAGNUSUNIVERSITYEgl÷Juškevičiūt÷TRANSCRIPTIONALREGULATIONINTHEEARLYPHASEOFLIVERREGENERATIONDoctoraldissertationPhysicalsciences,biochemistry(04P)Kaunas,2009VYTAUTODIDŽIOJOUNIVERSITETASEgl÷Juškevičiūt÷TRANSKRIPCINISANKSTYVOJOKEPENŲREGENERACIJOSTARPSNIOREGULIAVIMASDaktarodisertacijaFiziniaimokslai,biochemija(04P)Kaunas,2009 2The work described was carried out at Vytautas Magnus University and Thomas JeffersonUniversityin20022009.Researchsupervisor:Prof.habil.dr.VidaMildažien÷(VytautasMagnusUniversity)Consultant:Prof.dr. JanB.Hoek(ThomasJeffersonUniversity,Philadelphia) 3TABLEOFCONTENTSABBREVIATIONS ......................................................................................................................7INTRODUCTION ........................................................................................................................91 LITERATUREREVIEW ...................................................................................................121.1 Generalfeaturesofliverregeneration.........................................................................121.2 Cellularmechanismsofliverregeneration .................................................................141.3 Thehepatocytecellcycle.............................