Transcriptional profiling reveals barcode-like toxicogenomic responses in the zebrafish embryo [Elektronische Ressource] / presented by Lixin Yang

Transcriptional Profiling Reveals Barcode-Like Toxicogenomic Responses In The Zebrafish Embryo L. Yang Institut für Toxikologie und Genetik June 2007 Dissertation Submitted to the Combined Faculties for the Natural Sciences and for Mathematics of the Ruperto-Carola University of Heidelberg, Germany For the degree of Doctor of Natural Sciences Presented by Lixin Yang Shaanxi, China 2007 Tag der Mündlichen Prüfung: 31. 07. 2007 Transcriptional Profiling Reveals Barcode-Like Toxicogenomic Responses In The Zebrafish Embryo Gutacher: Prof. Dr. Uwe Strähle Prof. Dr. Thomas Braunbeck Abstract There is an increasing demand by regulators, pharmaceutical manufacturers and industry for reliable and ethically acceptable model systems to assess and predict the toxicity of pharmaceutical products, chemicals, and waste. In particular, developmental toxicity of compounds has largely been ignored in the past raising massive concerns. While cell lines have great merits as test systems, they do not reflect the complexity of a developing embryo.