Trans-Golgi network as independent organelle from Golgi apparatus in plant cells [Elektronische Ressource] / vorgelegt von Giovanni Stefano

Trans-Golgi Network as independent organelle from Golgi apparatus in plant cells Dissertation zur Erlangung des Doktorgrades (Dr. rer. nat.) der Mathematisch-Naturwissenschaftlichen Fakultät der Rheinischen Friedrich-Wilhelms-Universität Bonn vorgelegt von Giovanni Stefano aus San Pietro Vernotico, ITALY Bonn, 2009 Angefertigt mit Genehmigung der Mathematisch-Naturwissenschaftlichen Fakultät der Rheinischen Friedrich-Wilhelms-Universität Bonn 1. Referent: Prof. Dr. Diedrik Menzel 2. Referent: Prof. Stefano Mancuso Tag der Promotion: 23 July 2009 Diese Dissertation ist auf dem Hochschulschriftenserver der ULB Bonn http://hss.ulb.unibonn.de/diss_online elektronisch publiziert. Erscheinungsjahr: 2009 SUMMARY III SUMMARY In eukaryotic cells, GTPase-Activating Proteins (GAPs) are a family of proteins, which acts on small GTP-binding proteins of the Ras superfamily. GAP proteins have a conserved structure and use similar mechanisms, promoting hydrolysis of GTP to GDP. GAPs include several groups based on their substrate proteins, such as ARF (ADP Ribosylation Factor) GAPs, RAB (RAS-like protein in Brain) GAPs, and RHO (RAS Homologue) GAPs. ARFGAPs act specifically inducing hydrolysis of GTP on ARFs. In Arabidopsis thaliana genome, there are 15 proteins with ARFGAP domains (named AGD1-15) which are classified as ARFGAP Domain (AGD) proteins.