Towards structure and dynamics of metabolic networks [Elektronische Ressource] / eingereicht von Sergio Grimbs

Towards structure and dynamics ofmetabolic networksDissertationzur Erlangung des akademischen Grades einesDoktors der Naturwissenschaften (Dr. rer. nat.)der Mathematisch-Naturwissenschaftlichen Fakulta¨tder Universita¨t Potsdameingereicht vonSERGIO GRIMBSArbeitsgruppe BioinformatikMax-Planck-Institut fu¨r molekulare PflanzenphysiologiePotsdam, im Januar 2009This work is licensed under a Creative Commons License: Attribution - Noncommercial - Share Alike 3.0 Germany To view a copy of this license visit http://creativecommons.org/licenses/by-nc-sa/3.0/de/deed.en Published online at the Institutional Repository of the University of Potsdam: URL http://opus.kobv.de/ubp/volltexte/2009/3239/ URN urn:nbn:de:kobv:517-opus-32397 [http://nbn-resolving.org/urn:nbn:de:kobv:517-opus-32397] AbstractThis work proposes solutions for several issues pertaining to metabolic network modelling, rang-ingfromnetworkreconstructiontomultistabilityanalysistonewmodellingstrategiescopingwithunreliable kinetic parameters. The emphasis is on the close connection between structure anddynamicalbehaviourofmetabolicnetworks.High-throughput data fromvarious “omics” and sequencing techniques haverendered the au-tomated metabolic network reconstruction a highly relevant problem.