Tolerogenic dendritic cells in ret transgenic mouse model of spontaneous melanoma [Elektronische Ressource] / presented by Fang, Zhao

Dissertation submitted to the Combined Faculties for the Natural Sciences and for Mathematics of the Ruperto-Carola University of Heidelberg, Germany for the degree of Doctor of Natural Sciences presented by Diplom-Pharmacy: Fang, Zhaoborn in: Hebei province, ChinaOral-examination: Tolerogenic dendritic cells in ret transgenic mouse model of spontaneous melanoma Referees: Prof. Dr. Viktor Umansky PD. Dr. Anne Regnier-Vigouroux The present work (1.10.2005-1.8.2008) was done in the research group led by Prof. Dr. Viktor Umansky, clinical cooperation unit for Dermato-Oncology, German Cancer Research Center (DKFZ) and University Hospital Mannheim. Publications during PhD work: Umansky, V., Abschuetz, O., Osen, W., Ramacher, M., Zhao, F., Kato, M., and Schadendorf, D. Melanoma specific memory T cells are functionally active in Ret transgenic mice without macroscopical tumors. Cancer Res. 2008. (in press) Zhao, F., Falk, C., Osen, W., Kato, M., Schadendorf, D., and Umansky, V. Activation of p38 MAPK drives dendritic cells to become tolerogenic during melanoma development in ret transgenic mouse model. 2008. (submitted) Work presention in conferences: Zhao, F., Osen, W., Schadendorf, D., and Umansky, V. Study of dendritic cells in Ret-transgenic mouse model of spontaneous melanoma. 2007.