Three-dimensional electron microscopy of structurally heterogeneous biological macromolecules [Elektronische Ressource] / submitted by Florian Hauer

Three-dimensional electron microscopy of structurally heterogeneous biological macromolecules PhD Thesis in partial fulfilment of the requirements for the degree “Doctor of Philosophy (PhD)” in the Molecular Biology Graduate Program at the Georg August University Göttingen Faculty of Biology submitted by Florian Hauer born in Karlsruhe, Germany 2009 Members of Thesis Committee First Referee: Prof. Dr. Holger Stark Second Referee: Prof. Dr. Ralf Ficner Third Referee: Prof. Dr. Reinhard Jahn Affidavit I hereby declare in lieu of oath that this thesis has been written independently and with no other sources and aids than quoted. Göttingen, 31.05.2009 Florian Hauer List of Publications 1. Sirajuddin, M., Farkasovsky, M.. Hauer, F.. Kuhlmann, D., Macara, I. G., Weyand, M.. Stark, H., Wittinghofer, A.., Structural insight into filament formation by mammalian septins. Nature, 2007. 449(7160): p. 311-5. 2. Kastner, B., Fischer, N., Golas, M. M., Sander, B., Dube, P., Boehringer, D., Hartmuth, K., Deckert, J., Hauer, F., Wolf, E., Uchtenhagen, H., Urlaub, H., Herzog, F., Peters, J. M., Poerschke, D., Luhrmann, R., Stark, H., GraFix: sample preparation for single-particle electron cryomicroscopy. Nat Methods, 2008. 5(1): p. 53-5. 3. Schmeisser, M., Heisen, B.C., Luettich, M., Busche, B., Hauer, F., Koske, T., Knauber, K.-H.