Therapeutic in vitro and in vivo approach of influenza virus infection by simultaneous reduction of virus titre and cytokine expression through inhibition of virus-induced {NF-_k63B [NF-kappa-B] and Raf-MEK-ERK activation [Elektronische Ressource] / by Pinto, Ana Ruth Jorge Portugal Machado

Therapeutic in vitro and in vivo approach of influenza virus infection by simultaneous reduction of virus titre and cytokine expression through inhibition of virus-induced NF- B and Raf-MEK-ERK activationInaugural Dissertationsubmitted to theFaculty of Medicinein partial fulfilment of the requirementsfor the PhD-Degreeof the Faculties of Veterinary Medicine and Medicineof the Justus Liebig University GiessenbyPinto, Ana Ruth Jorge Portugal MachadoofLisbon, PortugalGiessen 2008From the Institute of Medical VirologyHead: Prof. Dr. Wolfram Gerlichof the Justus Liebig University GiessenFIRST SUPERVISOR AND COMMITTEE MEMBER: Prof. Dr. Stephan PleschkaSECOND SUPERVISOR AND COMMITTEE MEMBER:Prof. Dr. Stephan LudwigCOMMITTEE MEMBERS: Prof. Dr. Heinz-Juergen Thiel (Chairman)Prof. Dr. Juergen LohmeyerDate of Doctoral Defense: 9 December 2008I. Table of ContentsI. Table of contentsI. TABLE OF CONTENTS............................................................................................III. LIST OF FIGURES................................................................................................. VIII. LIST OF TABLES ................................................................................................ VIIV. ABBREVIATIONS .............................................................................................. VIIV. SUMMARY ...........................................................................................................