The role of the Ras guanyl-nucleotide exchange factor Rasgrp1 in synaptic transmission [Elektronische Ressource] / submitted by Simon Rolf Bungers

The Role of the Ras Guanyl-Nucleotide Exchange Factor Rasgrp1 in Synaptic Transmission Dissertation in partial fulfillment of the requirements for the degree “Doktor rerum naturalium” in the GAUSS Program at the Georg-August-University-Göttingen, Faculty of Biology. Submitted by Simon Rolf Bungers Born in Bonn, Germany June 2010 Declaration I hereby declare that this dissertation “The Role of the Ras Guanyl-Nucleotide Exchange Factor Rasgrp1 in Synaptic Transmission” has been written independently, with no other aids than those cited. I also declare that I am not enrolled or have applied for another university in order to graduate with the degree “Doktor rerum naturalium”. thGöttingen, 7 of June, 2010 Simon Rolf Bungers This dissertation was written at the Max-Planck-Institute of Experimental Medicine in the Department of Molecular Neurobiology. st1 Corrector: Prof. Dr. Nils Brose nd2 Corrector: Prof. Dr. Ralf Heinrich Supervisor: Dr. Andrea Betz/ Prof. Dr. Nils Brose thDate of the Disputatio: June 24 , 2010 Table of Contents Table of Contents Index of Figures ...................................................................................... 4 Index of Tables ........................................................................................ 5 Abbreviations .......................................................................................... 6 I.