The role of the {IL-15Rα [IL-15R-alpha] cytoplasmic domain in the IL-15 signal transduction pathway [Elektronische Ressource] / vorgelegt von Mojgan Drasdo

The role of the IL-15Rα cytoplasmic domain in the IL-15 signal transduction pathway Dissertation zur Erlangung des Doktorgrades des Fachbereichs Biologie der Universität Hamburg vorgelegt von Mojgan Drasdo Hamburg 2004 Für Jens, meinen Vater und in Gedenken meiner Mutter Index Figures .................................................................................................................................... IV SUMMARY.......1 1 INTRODUCTION............................................................................................................2 1.1 IL-15...........................................................................................................................2 1.2 The IL-15 receptor alpha (IL-15Rα) ..........................................................................3 1.3 Signal transduction pathway of IL-15/IL-15Rα.........................................................6 1.3.1 Signalling via heterotrimeric IL-15Rα/IL-2Rβ/IL-2Rγ complex.......................6 1.3.2 IL-15Rα/Syk signalling......................................................................................8 1.3.3 IL-15Rα/TRAF2 signalling................................................................................9 1.3.4 IL-15Rα endosomal internalisation pathway ...................................................12 1.