The role of the apoptosis and splicing associated protein Acinus during apoptotic nuclear changes [Elektronische Ressource] / vorgelegt von Alvin Paul Joselin

The role of the apoptosis and splicing associated protein Acinus during apoptotic nuclear changes Inaugural-Dissertation zur Erlangung des Doktorgrades der Mathematisch-Naturwissenschaftlichen Fakultät der Heinrich-Heine-Universität Düsseldorf vorgelegt von ALVIN PAUL JOSELIN aus Nagercoil, Indien Düsseldorf, 2006 Aus dem Institut für Molekulare Medizin der Heinrich-Heine Universität Düsseldorf Gedruckt mit der Genehmigung der Mathematisch-Naturwissenschaftlichen Fakultät der Heinrich-Heine-Universität Düsseldorf Referent: Prof. Dr. Klaus Schulze-Osthoff Koreferent: Prof. Dr. Heinz Mehlhorn Tag der mündlichen Prüfung: 09 Nov 2006 Acknowledgements I. ACKNOWLEDGEMENTS This work was performed at the Institut für Molekulare Medizin, Heinrich-Heine-Universität Düsseldorf. I would like to thank Prof. Dr. Klaus Schulze-Osthoff for his support, encouragement and advise concerning the project. I would also like to thank Dr. Christian Schwerk, my supervisor and mentor, for his invaluable discussions, criticisms and timely motivation, which helped me on to thinking independently and acquiring the skills that I needed to perform experimentation successfully. I thank Prof. Dr. Heinz Mehlhorn for making it possible for me to present this thesis. I am grateful to Fr. Dr. med. Grete Berns and Dr. Matthias Drechsler for their help with performing pulsed-field gel electrophoresis.