The role of oncogenic Cbl mutants in Kit signaling and myeloid transformation [Elektronische Ressource] / by Srinivasa Rao Bandi

The role of oncogenic Cbl mutants in Kit signaling and myeloid transformation Dissertation to obtain the Degree of Doctor of Philosophy at the Faculty of Natural Sciences Submitted to the Faculty of Biochemistry, Chemistry and Pharmacy of the Goethe University in Frankfurt am Main By Srinivasa Rao Bandi from India Frankfurt am Main, 2009 (D30) Submitted to the Faculty of Biochemistry, Chemistry and Pharmacy of The Goethe University in Frankfurt am Main Dean: Prof. Dr. Dieter Steinhilber Examiners: 1. Examiner: Prof. Dr. Rolf Marschalek 2. Examiner: Prof. Dr. Hubert Serve Date: Contents Contents Summary ............................................................................................................................... 4 1 Introduction .................................................................................... 6 1.1 Hematopoiesis ........................................................................................................ 6 1.2 Leukemia ......................... 6 1.2.1 Classification of leukemia ................................................................. 7 1.2.2 Acute myeloid leukemia (AML) ......................................... 8 1.