The role of NPxY domains in LRP1 receptor maturation and function [Elektronische Ressource] / von Thorsten Pflanzner

The role of NPxY domains in LRP1 receptor maturation and function Dissertation zur Erlangung des Grades „Doktor der Naturwissenschaften“ am Fachbereich Biologie der Johannes Gutenberg-Universität in Mainz von Thorsten Pflanzner geboren am 27. Februar 1981 in Nürnberg Mainz, im Dezember 2010 1 Dekan: 1. Berichterstatter: 2. Berichterstatter: Tag der mündlichen Prüfung: 2 TABLE OF CONTENTS 1. INTRODUCTION ............................................................................................................5 1.1. The low density lipoprotein receptor-related protein 1 (LRP1)...............................5 1.2. Early embryonic lethality of LRP1 deficient mice....................................................5 1.3. LRP1 in Alzheimer’s Disease (AD) ...........................................................................7 1.4. The BBB in AD...........................................................................................................8 1.4.1. Transporter-mediated clearance...........................................................................10 1.4.2. Receptor-mediated clearance...............................................................................13 1.5. Aims of the study......................................................................................................14 2. MATERIALS AND METHODS.......................................