The role of NBS1 in the insulin-like growth factor-1 signaling [Elektronische Ressource] / submitted by Arunee Hematulin

THE ROLE OF NBS1 IN THE INSULIN-LIKE GROWTH FACTOR-1 SIGNALING DISSERTATION DER FAKULTÄT FÜR BIOLOGIE DER LUDWIG-MAXIMILIANS-UNIVERSITÄT MÜNCHEN SUBMITTED BY ARUNEE HEMATULIN JUNE 19, 2008 1. Examiner: Prof. Dr. Eckardt-Schupp 2. Examiner: PD Dr. Friedl 3. Examiner: Prof. Dr. Cremer 4. Examiner: Prof. Dr. Koop 5. Examiner: Prof. Dr. Weiß 6. Examiner: PD Dr. Böttger Oral examination: June 13, 2008 IIIACKNOWLEDGEMENTS I wish to express my gratitude and deepest appreciation to my “Doktormutter” Professor Dr. Friederike Eckardt-Schupp for her excellent guidance, and kindness encouragement throughout this study. This thesis could not have accomplished without her understanding and gracious assistance. I wish like to express my deepest gratitude to Dr. Simone Mörtl and Dr. Daniel Sagan for their excellent guidance and training. Their valuable advice and support were very helpful for this thesis. I would like to thank all examining committee members for their valuable suggestions and corrections of this thesis. I would like to thank Dr. Hedda Eichholtz-Wirth for her valuable comments and suggestions, Dr. Wolfgang Beisker for assistance with cell cycle analysis, and all members of the DNA-repair group for their kindness and friendship.