The role of glia during striatal ontogenesis [Elektronische Ressource] : convergence of the major developmental signals on astrocytes / Veronica Ines Brito

Universität Ulm Abteilung Anatomie und Zellbiologie Leiter: Prof. Dr. Tobias Böckers The role of glia during striatal ontogenesis: Convergence of the major developmental signals on astrocytes Dissertation zur Erlangung des Doktorgrades der Humanbiologie an der Fakultät für Medizin der Universität Ulm vorgelegt von Veronica Ines Brito aus Argentinien, Cordoba 2004 Amtierender Dekan: Prof.Dr. Med. R. Marre 1. Gutachter: Prof. Dr. Cordian Beyer 2. Gutachter: Prof. Dr. Stephan Grissmer Tag der Promotion: 18.06.2004 A mis Padres For my Parents 1 TABLE OF CONTENTS Abbreviations…………………………………………………………………………. ..3 1. INTRODUCTION……………………………………………………………………. ..5 1.1. The striatum: A major component of the basal ganglia…………………………. 5 1.2. Striatal development……………………………………………………………... 7 1.2.1. Differentiation and compartmentation……………………………………....... 7 1.2.2. Developmental signals……………………………………………………...... 9 1.2.2.1. Neurotransmitters: Dopamine and glutamate……………………………. 10 1.2.2.2. Neurotrophins……………………………………………………………. 12 1.3.