The role of CYLD in dendritic cell function [Elektronische Ressource] / Cathy Cecilia Srokowski

The Role of CYLD in Dendritic Cell Function Dissertation to achieve the degree “Doktor der Naturwissenschaften” in the Faculty of Biology at the Johannes Gutenberg-Universität Mainz Cathy Cecilia Srokowski Mainz, November 2008 This thesis is dedicated to my mother 2 Acknowledgements: Thank you to all the members of the laboratory for their scientific advice and friendship. 3 TABLE OF CONTENTS LIST OF FIGURES AND TABLE.................................................................... 7 ABBREVIATIONS USED............... 8 ABSTRACT ................................................................................................... 11 1. INTRODUCTION..................................................................................... 12 1.1. Dendritic Cells......................................13 1.1.1. The role of dendritic cells in the immune system: immunity and tolerance...14 1.1.2. Antigen Processing: the choice between two pathways..................................16 1.1.3. Toll like receptors on dendritic cells ...............................................................18 1.1.4. Dendritic cells and DALIS: ubiquitin aggregates with DRiPs........................20 1.2. Ubiquitination.......................................................................................................................................21 1.3. NF-κB..................