The role of B cells during acute and latent infections with murine cytomegalovirus and Leishmania major [Elektronische Ressource] / Filiz Demircik

The role of B cells during acute and latent infections with murine cytomegalovirus and Leishmania major Dissertation zur Erlangung des Grades Doktor der Naturwissenschaft (Dr. rer. nat.) Am Fachbereich der Biologie der Johannes Gutenberg-Universität Mainz Filiz Demircik Geboren am 28. Mai 1980 in Bremen Mainz, 2011 Table of contents 1. INTRODUCTION......................................................................................... 1 1.1 B CELLS................................... 1 1.1.1. Antibodies....................... 2 1.1.2. B Cells as antigen presenting cells................................................. 3 1.1.3. B cells as IL-10 secreting cells....................... 4 1.2. DIFFERENT MOUSE MODELS WITH DEFICIENCIES IN THE B CELL COMPARTMENT............................................................................................... 5 1.3. MURINE CYTOMEGALOVIRUS (MCMV)....................... 7 1.3.1 Infection of the host cell................................... 8 1.3.2. Gene expression and virus replication............ 9 1.3.3 Latency and reactivation................................ 10 1.3.4 Relevance of hCMV....................................... 11 1.3.5 mCMV as model system for CMV infection... 11 1.3.6 Immunologic control of CMV infection........... 12 1.3.