The rabies virus phosphoprotein P [Elektronische Ressource] : a key regulator of innate immune responses / vorgelegt von Krzysztof Brzózka

The rabies virus phosphoprotein P: a key regulator of innate immune responses Dissertation der Fakultät für Biologie der Ludwig-Maximilians-Universität München zur Erlangung des Dr. rer. nat. vorgelegt von Krzysztof Brzózka München, April 2006 Erstgutachter: PD Dr. Bettina Kempkes Zweitgutachter: Prof. Dr. Michael Boshart Sondergutachter: Prof. Dr. Karl-Klaus Conzelmann Tag der mündlichen Prüfung: 22 November 2006 TABLE OF CONTENTS 1 TABLE OF CONTENTS 1 TABLE OF CONTENTS ....................................................................................................................... 3 2 ABBREVIATIONS ................................................................................................................................4 3 INTRODUCTION... 6 3.1 RABIES VIRUS (RV) ........................................................................................................................ 6 3.1.1 Pathogenicity ......................................................................................................................... 6 3.1.2 Virus structure and replication............................................................................................. 7 3.1.3 Multifunctional phosphoprotein P ....................................................................................... 9 3.2 INNATE IMMUNITY: INTERFERON ...........................