The MHC II ligandome [Elektronische Ressource] : mass spectrometric applications in immunology = Das MHC-II-Ligandom / vorgelegt von Jörn Dengjel

The MHC II Ligandome Mass Spectrometric Applications in Immunology Das MHC II Ligandom Massenspektrometrische Anwendungen in der Immunologie DISSERTATION der Fakultät für Chemie und Pharmazie der Eberhard-Karls-Universität Tübingen zur Erlangung des Grades eines Doktors der Naturwissenschaften 2005 vorgelegt von Jörn Dengjel II III Tag der mündlichen Prüfung: 24.01.2005 Dekan: Prof. Dr. S. Laufer 1. Berichterstatter: Prof. Dr. S. Stevanovi ć 2. Berichterstatter: Prof. Dr. H.-G. Rammensee IV V Preface Some of the chapters of this thesis are parts of publications. At the beginning of each chapter it is indicated which experiments where done by the author of the thesis, which persons contributed to the publication, and in which journals the work was published. VI Table of Contents 1 Table of Contents TABLE OF CONTENTS 1 1 INTRODUCTION 3 1.1 The immune system 3 1.1.1 Major histocompatibility complex molecules and antigen processing 4 1.1.2 T lymphocytes and anti-tumor immunotherapy 6 1.2 Mass spectrometry 9 1.2.1 MALDI-TOF mass spectrometry 10 1.2.2 ESI-quadrupole-TOF mass spectrometry 11 1.