The generation and the characterization of the TASK-3 knockout mice [Elektronische Ressource] / presented by Cristina Gabriela Sandu

DISSERTATION submitted to the Combined Faculties for the Natural Sciences and for Mathematics of the Ruperto-Carola University of Heidelberg, Germany for the degree of Doctor of Natural Sciences presented by Biologist Cristina Gabriela Sandu born in Buzau, Romania oral examination: 28.03.2006 The generation and the characterization of the TASK-3 knockout mice Gutachter: Prof. Dr. Peter Seeburg Prof. Dr. Hannah Monyer Table of contents 1 INTRODUCTION......................................................................................................................1 1.1 Membrane potential............................................................................................................2 1.2 Potassium channels....4 1.3 Two pore domain (K2P) potassium channels.....................................................................5 1.3.1 Classification of the mammalian K2P genes .......................................................................... 6 1.3.2 The expression of the K2P gene family in adult mouse brain .............................................. 10 1.3.3 Functional Characteristics of the K2P gene family............................................................... 13 1.4 TASK channel subfamily: TASK-1, TASK-3 and TASK-5 ..........................................