The functional relevance of MKK4 and MKK7 splice variants in neural cells [Elektronische Ressource] / vorgelegt von Wiebke Häusgen

The functional relevance of MKK4 and MKK7 splice variants in neural cells Dissertation zur Erlangung des Doktorgrades der Mathematisch-Naturwissenschaftlichen Fakultät der Christian-Albrechts-Universität zu Kiel vorgelegt von Dipl.-Biol. Wiebke Häusgen Kiel 2010 Referent: Prof. Dr. Thomas Herdegen Korreferent: Prof. Dr. Manuela Dittmar Tag der mündlichen Prüfung: 30. November 2010 Zum Druck genehmigt: 30. November 2010 gez. Prof. Dr. Lutz Kipp, Dekan Meinen ElternTable of contents I Table of contents 1 Introduction.............................................................................. 1 1.1 Mitogen-activated protein kinase kinase 4 ..................................................................2 1.2 Mitogen-activated protein kinase kinase 7 ..................................................................4 1.3 The c-Jun N-terminal kinases......................................................................................6 1.4 Regulation of JNKs by MKK4 and MKK7.................................................................8 1.5 PC12 cells- a versatile model for peripheral mammalian neurons..............................9 1.6 Aims of the study.......................................................................................................10 2 Materials and methods.....................