The anti-inflammatory cytokine recombinant human interleukin-11 inhibits activation of the transcription factors {NF-_k63B [NF-kappa-B] and AP-1 in pancreatic islets and prevents diabetes induced with multiple low doses of streptozotocin in male C57BL/6 mice [Elektronische Ressource] / vorgelegt von Abdelhakim Lgssiar

TABLE OF CONTENTSThe anti-inflammatory cytokine recombinant human interleukin-11inhibits activation of the transcription factors NF-kB and AP-1 inpancreatic islets and prevents diabetes induced withmultiple low doses of streptozotocinin male C57BL/6 miceI n a u g u r a l – D i s s e r t a t i o nzurErlangung des Doktorgrades derMathematisch-Naturwissenschaftlichen Fakultätder Heinrich-Heine-Universität Düsseldorfvorgelegt vonAbdelhakim Lgssiaraus Marrakesch (Marokko)TABLE OF CONTENTSVeröffentlicht mit der Genehmigung der Mathematisch-Naturwissenschaftlichen Fakultätder Heinrich-Heine-Universität DüsseldorfDekan: Prof. Dr. rer. nat. Gerd FischerProdekan: Prof. Dr. rer. nat. Peter Westhoff1. Berichterstatter: Prof. Dr. med. Helga Gleichmann2. Berichterstatter: Prof. Dr. rer. nat. Frank WunderlichTag der mündlichen Prüfung: 24.05.2004TABLE OF CONTENTSTABLE OF CONTENTS1. INTRODUCTION ....................................................................................... 11.1 Type 1 diabetes -T1D -: general aspects................................... 11.2 The Th1/Th2 concept................................................................. 21.2.1 In immune reactions........................................................ 21.2.2 In T1D.............................................................................. 31.3 NF-kB and AP-1 in immune responses...................................... 51.3.