The analysis of doxorubicin-loaded poly(butyl cyanoacrylate) nanoparticles in in vitro glioma models [Elektronische Ressource] / von Berta Sanchez de Juan

The analysis of doxorubicin-loaded poly(butylcyanoacrylate) nanoparticles in in vitro glioma modelsDissertationzur Erlangung des Doktorgradesder Naturwissenschaftenvorgelegt beim Fachbereich 14Biochemie, Chemie und Pharmazieder Johann-Wolfgang-Goethe Universityin Frankfurt am MainvonBerta Sanchez de JuanausMadrid, SpanienFrankfurt am MainNovember 2005Dedicado a Joaquin y MercheAcknowledgementsThe following thesis benefited from the insights and direction of several people. First, I wouldlike to acknowledge Professor Dr. Jörg Kreuter for allowing me to work on his group as PhD-student and particularly for encouraging me to develop independent and self-sufficientapproach to my work. I also wish to thank Hagen von Briesen for his scientific support and Ispecially would like to thank Dr. Svetlana Gelperina for her very refreshing support, andfor her limitless passion for science.I am very grateful to the Deutsche Forschungsgemeinschaft (DFG), GraduiertenkollegArzneimittel: Entwicklung und Analytik and INTAS grant 00-838, who supported this work.I am also very grateful to the Chemotherapeutic Institute Georg-Speyer-Haus, where the mostimportant work was carried out.I would like to express my sincere thanks to all the member of the institute of pharmaceuticaltechnology at the University of Frankfurt, and in particular to my colleagues AlessandraAmbruosi, Alexander Bootz, Telli Hekmatara for a great work atmosphere and veryunforgettable moments.