Targeting of adenovirus gene transfer vectors via combined geneti chemical modification of the minor capsid protein IX [Elektronische Ressource] / Stéphanie Corjon
Division of Gene Therapy Director: Stefan Kochanek Targeting of adenovirus gene transfer vectors via combined geneti-chemical modification of the minor capsid protein IX. Dissertation zur Erlangung des Doktorgrades der Humanbiologie der Medizinischen Fakultät der Universität Ulm Stéphanie Corjon Saint Martin d’Hères (France) 2008 Amtierender Dekan Prof. Dr. Klaus-Michael Debatin 1. Berichterstatter Prof. Dr. Stefan Kochanek 2. Berichterstatter Prof. Dr. Thomas Mertens Tag der Promotion 21th of july, 2008 Table of contents Abbreviation list.............................................................................................................................III 1 Introduction............................................................................................................................1 1.1 Gene therapy .................................................................................................................. 1 1.2 Classification of adenoviruses ......................................................................................... 6 1.3 Biology of adenoviruses .................................................................................................. 7 1.3.1 Structure of the virions ............................................................................................. 7 1.3.