T-cell receptor assay and reticulocyte-micronuclei assay as biological dosimeters for ionizing radiation in humans [Elektronische Ressource] / vorgelegt von Stanislav Vershenya

Aus der Klinik und Poliklinik der Nuklearmedizinder Universität WürzburgDirektor: Prof. Dr. med. Chr. ReinersT-cell receptor assay and reticulocyte-micronuclei assay as biological dosimeters for ionizing radiation in humansInaugural – Disserationzur Erlangung der Doktorwürde derMedizinische FakultätderBayerischen Julius-Maximilians-Universität zu Würzburgvorgelegt vonStanislav Vershenyaaus Minsk, WeißrusslandWürzburg, Mai 2007Referent: Prof. Dr. med. Dr. rer. nat. K. HempelKoreferent: Prof. Dr. med. Chr. ReinersDekan: Prof. Dr. med. M. FroschTag der mündlichen Prüfung: 17. September 2008Der Promovend ist ArztI dedicate this work to my family and thank them for all their support and love throughout all my years here, in Wuerzburg UniversityContents:1. Introduction................................................................................................... 12. Method.......................................................................................................... 32.1. Thyroid cancer patients and radioiodine treatment (RIT).............................. 32.2. Assays.......................................................................................................... 52.2.1. Standard T-Cell receptor (TCR) assay...................................................... 52.2.2. Assay for latent TCR mutants ................................................................... 52.2.2.1.