Systems biology perspectives on calcium signaling and DNA repair [Elektronische Ressource] / von Antonio Politi

Systems Biology Perspectives on Calcium Signalingand DNA RepairDISSERTATIONzur Erlangung des akademischen Gradesdoctor rerum naturalium(Dr. rer. nat.)im Fach Biophysikeingereicht an derMathematisch-Naturwissenschaftlichen Fakultät IHumboldt-Universität zu BerlinvonDiplom–Biophysiker Antonio Politigeboren am 29.10.1975 in FlorenzPräsident der Humboldt-Universität zu Berlin:Prof. Dr. Christoph MarkschiesDekan der Mathematisch-Naturwissenschaftlichen Fakultät I:Prof. Dr. Christian LimbergGutachter:1. Prof. Thomas Höfer, PhD2. Prof. Dr. Hanspeter Herzel3. Prof. Dr. Hermann-Georg Holzhüttereingereicht am: 6. November 2006Tag der mündlichen Prüfung: 26. März 2007AbstractThis work deals with two paradigms of cellular signaling: a change in the intracellular2+Ca concentration represents often one of the first steps in the transduction of incomingstimuli; the ability to properly respond to external injuries and repair damaged DNA2+is an essential component for life. The approaches used to investigate Ca signalingand DNA repair bear common points. Mathematical models are used to asses systemproperties, such as efficiency in the signal processing, specificity of the response, anddesign principles behind the different pathways. A close collaboration with experimen-talist made it possible to directly compare model predictions and experimental data,and to test different mechanistic hypothesis.