Systematic Identification of Scaffolds Representing Different Types of Structure-Activity Relationships [Elektronische Ressource] / Ye Hu

h-NaturwissenscSystematicoIdenRheiniscticationausofakSh-Wilhelms-UnivcaoldsonRepresenMarctinghenDierenlt?ttFTBonnypgelegtesHofChinaStructure-A2011ctivithaftlicyFRelationshipsuKumderulativheneriedricDissertationersit?tzurvErlangungrdesvDoktorgradesYe(Dr.ureJiangsu,r.Bonnnat.)h,derMathematiscDr.Angefertigtnat.mitt:Genehmigung2.derhaelMathematiscDr.h-NaturwissenscBahaftlict:henat.Fhoakult?tUniv.-Prof.derrer.RheiniscJ?rgenhenjorathFReferenriedricUniv.-Prof.h-Wilhelms-Univrer.ersit?tMicBonnG?tsc1.wReferenofAbstractyIncomedicinalsharecehemistrypromiscuous.,,itatisselectivofthecenagainsttraloundimpindiviortanceetowith,understandastructure-isactivitlatedyvrelationshipsscaolds(SARs)corre-ofandsmallpairwisebioactivyeaddition,compeounds.areTinypicallyrelationships,activitSARsidenareectivitanalyzedactivonthataunitiescase-bty-caseonebasisidenforromiseEightscofcompcompdierenoundsconsideredactivbeyagainsttheaformgivyenptarget.targetsHoectivwetevscaoldser,foundtheinincreasingwithamounto,tsubstructureofocompstagesoundFactivitaticyproledatadomaithatcompisout.bcompecomingforacloselyvandailableoundsallofwstargetSARsotherstoInbofeyexploredthoroughlyony-threeaeringlarge-scypale.ondMoreoactivvleaster,targetmolecularusscaoldsbderivvedinfromfoldbioactivceotencycompensioundsscaoldsareulti-targetalsoselofand,highglobalintialterestaforquanSARassessed,analysis..