Systematic {devolopment [development] of formulations suitable for pulmonary applications by nebulisation [Elektronische Ressource] / presented by Antonio Raposo

DISSERTATION SUBMITTED TO THE COMBINED FACULTIES FOR THE NATURAL SCIENCES AND FOR MATHEMATICS OF THE RUPERTO-CAROLA UNIVERSITY OF HEIDELBERG, GERMANY FOR THE DEGREE OF DOCTOR OF NATURAL SCIENCES PRESENTED BY ANTONIO RAPOSO, LIC. PHARM. BORN IN BARREIRO, PORTUGAL ORAL-EXAMINATION: 19.JUNE.2006 SYSTEMATIC DEVOLOPMENT OF FORMULATIONS SUITABLE FOR PULMONARY APPLICATIONS BY NEBULISATION Referees: Prof. Dr. Gert Fricker Priv. Doz. Dr. Ulrich Massing The following work was conducted at University of Heidelberg, Faculty of Biosciences, Institute for Pharmacy and Molecular Biotechnology, Dep. Pharmaceutical Technology and Pharmacology in cooperation with PARI GmbH Starnberg. First of all, I would like to thank Herrn Prof. Dr. Fricker for taking me as a doctorate student at his institute; Herrn Dr. Keller, director of the Aerosol Research Institute-PARI GmbH, for allowing me to perform the necessary experimental work at the PARI GmbH laboratories. To Herrn Dr. Bultmann, I would like personally to thank him for the guidance and advices given during this work. His encouragement, technical and editorial advice, suggestions, discussions and supervision were an invaluable support to complete this work. I am also very grateful to all my fellow colleagues at the Aerosol Research Institute-PARI GmbH for their assistance and companionship throughout my stay at PARI GmbH.