Synthesis of spirocyclic scaffolds by aminoallylation RCM sequence and approach toward the total synthesis of the Macrolide Dictyostatin [Elektronische Ressource] = Synthese spiroverknüpfter Scaffolds durch eine Aminoallylierung-, Ringschluss-Metathese-Sequenz und ein Zugang zur Totalsynthese des Macrolids Dictyostatin / vorgelegt von Evgeny V. Prusov

Synthesis of Spirocyclic Scaffolds by Aminoallylation/RCM Sequence and Approach Toward the Total Synthesis of the Macrolide Dictyostatin Synthese Spiroverknüpfter Scaffolds durch eine Aminoallylierung/Ringschluss Metathese Sequenze und ein Zugang zur Totalsynthese des Macrolids Dictyostatin DISSERTATION der Fakultät für Chemie und Pharmazie der Eberhard-Karls-Universität Tübingen zur Erlangung des Grades eines Doktors der Naturwissenschaften 2007 vorgelegt von Evgeny V. Prusov Tag der mündlichen Prüfung: Dekan: Prof. Dr. L. Wesemann 1. Berichterstatter: Prof. Dr. M. E. Maier 2. Prof. Dr. Th. Ziegler This doctoral thesis was carried out from August 2003 to October 2007 at the Institut für Organische Chemie, Fakultät für Chemie und Pharmazie, Eberhard-Karls-Universität Tübingen, Germany, under the guidance of Professor Dr. Martin E. Maier. Foremost, I am indebted to Prof. Dr. Martin E. Maier, my supervisor, for his support and excellent guidance during this research work. I thank him not only for providing me with the lab facilities but also for his confidence and unlimited trust in me and for the multitude of little advices he has given me during the course of this work. I personally thank Mr. Graeme Nicholson and Mr. Paul Schuler for their skilful technical assistance in numerous measurements, Mrs.