Synthesis of site-specific artificial ribonucleases [Elektronische Ressource] / von Claudio Gnaccarini

Synthesis of Site-Specific Artificial Ribonucleases Dissertation zur Erlangung des Doktorgrades der Naturwissenschaften vorgelegt beim Fachbereich Biochemie, Chemie und Pharmazie der Johann Wolfgang Goethe-Universität in Frankfurt am Main von Claudio Gnaccarini aus Verona (Italia) Frankfurt am Main 2007 (D30) Vom Fachbereich Biochemie, Chemie und Pharmazie der Johann Wolfgang Goethe-Universität als Dissertation angenommen. Dekan: Prof. Dr. H. Schwalbe 1. Gutachter: Prof. Dr. M. W. Göbel 2. Gutachter: Datum der Disputation: Acknowledgements First of all, I want to thank Professor Dr. Michael Göbel for the opportunity he gave me of working in his group and for supporting me during my studies. I thank Dr. Ute Scheffer and Elisabeth Kalden for the tests of RNA cleavage and the help during my biological experiments and I also thank Sascha Peter and Kathrin Beier for the collaboration in my projects. I am obliged to: Dr. Nelly Piton and Professor Dr. Joachim Engels for the deoxyuridine derivative, Dr. Jörg Bäumler and Dr. Manuel Grez for the Bcr-Abl peptide, Jérôme Désiré and Professor Dr.