Synthesis and conformational analysis of peptidomimetics containing unnatural amino acids based on a piperazinone and {γ-butyrolactone [gamma-butyrolactone] scaffolds [Elektronische Ressource] / vorgelegt von Karine Guitot

SYNTHESIS AND CONFORMATIONAL ANALYSIS OF PEPTIDOMIMETICS CONTAINING UNNATURAL AMINO ACIDS BASED ON A PIPERAZINONE AND -BUTYROLACTONE SCAFFOLDS Dissertation Zur Erlangung des Doktorgrades der Naturwissenschaften Dr. rer. nat. der Universität Insubria COMO (Italy) und der Fakultät für Chemie und Pharmazie der Universität Regensburg vorgelegt von Karine Guitot aus Paris (Frankreich) COMO 2008 UNDER THE SUPERVISION OF: PROFESSOR UMDERTO PIARULLI PROFESSOR OLIVER REISER gggg A Vincent Havage, A mes parents, à ma sœur, 2 Acknowledgements I would like to thank Professor Umberto Piarulli, my Supervisor from Italy who gave me the opportunity to participate in this research project. I would like to thank him in particular for his extreme patience and support from the first day of my thesis until the end. I would like also to thank Professor Oliver Reiser my Supervisor from Germany who welcomed me in his research team for the second part of this Thesis. I am grateful to Professor Chiara Cabrele, Professor Sames Sicsic and Dr. Sandrine Ongeri, for their precious advices during these three years. For the financial support, I am grateful to «Marie Curie Early Stage training Fellowship of the European Community’s sixth Framework Programme».