Super-specific DNA methylation by a DNA methyltransferase coupled with a triple helix-forming oligonucleotide [Elektronische Ressource] / vorgelegt von Maria Maluszynska-Hoffman

Super-specific DNA methylation by a DNA methyltransferase coupled with a triple helix-forming oligonucleotideVon der Fakultät für Mathematik, Informatik und Naturwissenschaften der RWTH Aachen University zur Erlangung des akademischen Grades einer Doktorin der Naturwissenschaften genehmigte Dissertationvorgelegt vonMaria Maluszynska-Hoffmanaus Poznań, PolenBerichter: Universitätsprofessor Dr. Elmar Weinhold Universitätsprofessor Dr. Markus Albrecht Tag der mündlichen Prüfung: 13.11.2008Diese Dissertation ist auf den Internetseiten der Hochschulbibliothek online verfügbar.This work has been carried out at the Institute of Organic Chemistry, RWTH Aachen University under the supervision of Prof. Dr. Elmar Weinhold from September 2005 to September 2008.I would like to thank Prof. Dr. Elmar Weinhold for giving me the great opportunity to come to Aachen and work in his research group. I am grateful for the very interesting and challenging project assignment, as well as for his guidance and encouragement throughout my study. I would like to thank Dr. Reinhold Wasserkort for his work on bisulfite sequencing. Dr. Marianne G. Rots, Dr. Marcel Ruiters and Ieneke van der Gun for carrying out the in vivo experiments and for their hospitality during my stay in Groningen.I would like to thank all participants of the IMEDGEN project for the stimulating partnership.