Studying the role of the fusion protein MLL-AF4 in leukemogenesis with the help of siRNAs [Elektronische Ressource] / von Maria Thomas (geb. Arkhipova)

Studying the role of the fusion protein MLL-AF4 in leukemogenesis with the help of siRNAs der Fakultät für Biologie der Eberhard Karls Universität Tübingen zur Erlangung des Grades eines Doktors der Naturwissenschaften von Maria Thomas (geb. Arkhipova) aus Pushchino (Russland) vorgelegte D i s s e r t a t i o n 2007 Tag der mündlichen Prüfung: 11.10.2006 Dekan: Professor Dr. F. Schöffl 1. Berichterstatter: Professor Dr. A. Nordheim 2. Berichterstatter: PD Dr. O. Heidenreich 3. Berichterstatter: Professor Dr. R. Marschalek To my deeply beloved parents, my first teachers and scientific encourages, my strictest judges and closest friends PUBLICATIONS PUBLICATIONS During the course of this work the following articles have been published or submitted for publication: Thomas M, Gessner A, Vornlocher HP, Hadwiger P, Greil J, Heidenreich O. (2005). Targeting MLL-AF4 with short interfering RNAs inhibits clonogenicity and engraftment of t(4;11)-positive human leukemic cells. Blood. 106, 3559-66. Thomas M, Greil J, Heidenreich O. (2006). Targeting leukemic fusion proteins with small interfering RNAs: recent advances and therapeutic potentials. Acta Pharmacol Sinica. 27, 273-81. Thomas M, Martinez Soria N, Heidenreich O. (2006). RNA Interference in Hematopoietic and Leukemic Cells. EDS. Systems of Biology, pp.