Studying integrin-mediated cell spreading using a biomimetic system [Elektronische Ressource] / put forward by Pia Streicher

OralfdegreeASTREICHERTIONrankreichsubmittedoftordtheWCombined8FraculDoctotiesScienceforwrythernNaturalrms,SciencesNovemberandDISSERTfofortheMathematicsofofrtheNaturalRuperto-CaPutrola-UniversitoyaofbHeidelberg,PiaGermanyboandintheoUniversitéGermanyPexamination:a2ris2008VI,FthDr.Dr.érieIntegrin-MediatedSpatzCellaSprchi-ArtznerreadingJoachimUsingProf.aVBiomimeticlSystemMaReferees:StudyingProf.experimentalthertedAbstracttied:Astudiednoveltightsystemuntilmimickinggrothebiofunctionalizedrsttostepssmoffointegrin-mediatedringcelladheringspsinglereadingredictedwthirdasdynamicsdevelopedtheandredictions.chaforacte200randiadhe-zed.theThisawrmedasregimesachievedthebereyroceedreconstitutingwthefotransmembasraneThepRrperimentallyoteicompanreticalintegrinadhesionEnglishthedata.ofexperimental(thedomainsmatchedwhichwhichfuseintoagiantpatchunilamellarderrzone.vesictolesthe(GUVts).unifoTheThreemethodereconsiostedregime,ofzonesaredicteddetergent-mediatedwithrecpowhichnstiwithtutiona.ofinsolubilizedeintegrinsixintosurface.smalladhesionpwroteoliposomessex-(0.1and-results0.