Study of human specific microglial receptor siglec-11 and generation of transgenic mice expressing human siglec 11 [Elektronische Ressource] / submitted by Yiner Wang

Study of Human-Specific Microglial Receptor Siglec-11 and Generation of Transgenic Mice Expressing Human Siglec-11 PhD Thesis In fulfillment of the requirements for the degree “Doctor of Philosophy (PhD)/Dr. rer. nat.” at the Faculty of Mathematics and Natural Sciences of the Rheinischen Friedrich-Wilhelms University of Bonn Submitted by Yiner Wang born in Zhejiang, China Bonn, March 2009 Angefertigt mit Genehmigung der Mathematisch-Naturwissenschaftlichen Fakultät der Rheinischen Friedrich-Wilhelms Universität Bonn. 1. Referent: Prof. Dr. Harald Neumann 2. Referent: Prof. Dr. Waldemar Kolanus Tag der Promotion: 25.06.2009 1 Dedicated to my families 2 Contents TABLE OF CONTENTS ABBREVIATIONS..........................................................................................................5 1 INTRODUCTION ........................................................................................................8 1.1 Siglecs........................................................................................................................................ 8 1.1.1 Definition and nomenclature of Siglecs..................................................................