Studies on the molecular interactions of collagen type XVI [Elektronische Ressource] / by Sabine Ratzinger

Studies on the molecular interactions of collagen type XVI Part I: The role of collagen XVI in pathological disorders Part II: Establishment of a retroviral mediated gene silencing model Dissertation to obtain the Degree of Doctor of Natural Sciences (Dr. rer. nat.) from the Faculty of Chemistry and Pharmacy University of Regensburg By Sabine Ratzinger from Unterötzdorf -September 2009- This work was carried out from January 2004 until June 2007 at the Department of Experimental Orthopaedics of the University Hospital Regensburg, Germany. Under the supervision of Prof. Dr. Roland Seifert and PD Dr. Susanne Grässel ndRequest for examination: September 2 , 2009 thDate of examination: November 27 , 2009 Examination board: Chairman: Prof. Dr. Sigurd Elz 1. reviewer: Prof. Dr. Roland Seifert 2. PD Dr. Susanne Grässel 3. examiner: Prof. Dr. Achim Göpferich ii iii“You have to love what you do, do what you have to do, you gotta work hard, as hard as you can, to move the stones out of your way.” Lyrics from “breathe” by Mohear iv Table of contents Table of contents 1. Abstract.............................................................................................. 1 2. Preface................................................................................................ 3 2.1 Molecular constituents of the ECM .......