Studies on the bovine herpesvirus 1 US3 protein kinase (BHV-1pUS3) [Elektronische Ressource] / Quang Minh Luu

Studies on the bovine herpesvirus 1 US3 protein kinase (BHV-1pUS3) Inauguraldissertation zur Erlangung des akademischen Grades Doctor rerum naturalium (Dr.rer.nat.) an der Mathematisch-Naturwissenschaftlichen Fakultät der Ernst-Moritz-Arndt-Universität Greifswald vorgelegt von Luu Quang Minh geboren am 18. Februar 1978 in Hanoi, Vietnam Greifswald, Insel Riems 12/2010 Dekan: Prof. Dr. Klaus Fesser 1. Gutachter: Prof. Dr. Dr. h.c. Thomas C. Mettenleiter 2. Gutachter: Prof. Dr. Klaus Osterrieder Tag der Promotion: 09/03/2011 Dedicated to all beloved members in my family including my parent, my parent in-law, especially my wife Le Thi Thanh Huong, my 6 year old daughter Luu Ha Phuong and my 11 month old son Luu Bao Khang. Table of contents TABLE OF CONTENTS Page ABBREVIATIONS 1 1. INTRODUCTION 31.1. Overview of Herpesviridae family 31.2. Bovine herpesvirus 1 (BHV-1) 71.2.1. Nomenclature, classification and pathogens 71.2.2. BHV-1 vaccines 91.2.2.1. Genetically engineered gene-deleted vaccines and vectored vaccines 91.2.2.2. Use of BHV-1 as a vaccine vector 101.2.3. Virion structure 101.2.4. Virus genome and proteins 111.2.5. BHV-1 replication cycle 141.2.5.1. Cell specificity 141.2.5.2. Virus entry into host cells 141.2.5.3.